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Isolation and Identification of Coumarins from Citrus latifolia Leaves Using Advanced Chromatographic Techniques.
Methods Mol Biol
January 2025
Laborotorio de Química de Products Naturales, Departmento de Biotecnologia y Bioquímica, Centro de Investigatión y de Estudios Avanzados de IPN, Guanajuato, Mexico.
Coumarins are a class of natural compounds that exhibit a wide range of biological activities, which include anticoagulant, anti-inflammatory, anticancer, and antimicrobial effects. This class of compounds has drawn considerable interest in recent years. The exploration of such properties contributes to our understanding of the potential of coumarins as valuable agents in various clinical applications.
View Article and Find Full Text PDFDevelopment of pyrazolo[1,5-a]pyrimidine-grafted coumarins as selective carbonic anhydrase inhibitors and tubulin polymerization inhibitors with potent anticancer activity.
Int J Biol Macromol
January 2025
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt. Electronic address:
This study presents the design, synthesis, and evaluation of a novel series of coumarin-based compounds (9a-t) as potential anticancer agents. The compounds were strategically designed to inhibit cancer-related carbonic anhydrase (CA) isoforms IX and XII and tubulin polymerization. Two approaches were employed for CA inhibition: utilizing the coumarin motif to occlude the CA active site entrance and incorporating zinc-binding groups (sulfonamide, carboxylic acid, and thiol) to interact with the catalytic zinc ion.
View Article and Find Full Text PDFIdentification of novel 7-hydroxycoumarin derivatives as ELOC binders with potential to modulate CRL2 complex formation.
Sci Rep
January 2025
Research Institute, National Cancer Center, Goyang-si, 10408, Gyeonggi, Republic of Korea.
The VHL-containing cullin-RING E3 ubiquitin ligase (CRL2) complex is an E3 ligase commonly used in targeted protein degradation (TPD). Hydroxyproline-based ligands that mimic VHL substrates have been developed as anchor molecules for proteolysis-targeting chimeras (PROTACs) in TPD. To expand the chemical space for VHL ligands, we conducted fragment screening using VHL-ELOB-ELOC (VBC) proteins.
View Article and Find Full Text PDFAqueous extracts of and as promising sources of antibiofilm compounds against mucoid and small colony variants of and .
Biofilm
June 2025
Centre of Biological Engineering, LIBRO - Laboratório de Investigação em Biofilmes Rosário Oliveira, University of Minho, Campus de Gualtar, Braga, 4710-057, Portugal.
Bacterial biofilms formed by and pose significant challenges in treating cystic fibrosis (CF) airway infections due to their resistance to antibiotics. New therapeutic approaches are urgently needed to treat these chronic infections. This study aimed to investigate the antibiofilm potential of various plant extracts, specifically targeting mucoid and small colony variants of and and strains.
View Article and Find Full Text PDFEfficacy of plant extracts against the immature stage of house fly, Musca domestica (Diptera: Muscidae).
Trop Biomed
December 2024
Department of Entomology and Plant Pathology, Khon Kaen University, Thailand Mittapap Road, Khon Kaen, Khon Kaen, 40002, Thailand.
This research aimed to find indigenous plants and suitable solvents to extract substances with the capacity to suppress the immature stages of house fly populations in animal farms and urban areas. Seven native Thai plants were tested: Alstonia scholaris (L.) R.
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