AI Article Synopsis
- A new compound and 13 known compounds were isolated from the Aspergillus niger fungus found in Pachysandra terminalis in China, with detailed structure analysis conducted on the new compound.
- Compounds 5, 6, 8, and 14 are reported from Aspergillus for the first time, while compound 2 is newly isolated from A. niger.
- Compounds 2 and 3 showed strong antioxidant activities, while compound 1 exhibited significant α-glucosidase inhibition, making it a promising candidate for further development.
Article Abstract
One new compound and 13 known compounds were isolated from Aspergillus niger, a plant endophytic fungus of Pachysandra terminalis collected from Qinling Mountains, Xi'an, China. The structure of new compound 1 was classically determined by extensive spectroscopic analysis. Compounds 5, 6, 8, and 14 were first reported from Aspergillus, while compound 2 was isolated from A. niger for the first time. All isolated compounds were further evaluated for their antioxidant and α-glucosidase inhibitory activities. Compounds 2 and 3 exhibited significant antioxidant activities with IC50 values of 31.64 μm and 24.32 μm, respectively, similar to the positive control ascorbic acid. Additionally, compound 1 displayed remarkable inhibitory activity against α-glucosidase with an IC50 value of 96.25 μm, which was 3.4-fold more potent than that of the positive control acarbose. Compound 1 has great potential for development as a new lead compound owing to its simple structure and remarkable biological activity.
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| http://dx.doi.org/10.1093/bbb/zbac137 | DOI Listing |
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