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Clinicopathologic Findings in Chickens () Administered Amikacin Through Intravenous Regional Limb Perfusion. | LitMetric

Clinicopathologic Findings in Chickens () Administered Amikacin Through Intravenous Regional Limb Perfusion.

J Avian Med Surg

Department of Surgical Science, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA.

Published: August 2022

AI Article Synopsis

  • Regional limb perfusion (RLP) is a method used to treat infections in the limbs of birds, particularly chickens.
  • A study tested the safety of administering amikacin, a potentially harmful drug, through RLP to see if it causes kidney damage.
  • Results showed no significant kidney issues in treated chickens compared to control chickens, indicating RLP with amikacin is safe for healthy birds.

Article Abstract

Regional limb perfusion (RLP) has been used to treat cases of distal limb infections in avian species. Potentially nephrotoxic drugs, such as amikacin, may increase the risk of nephrotoxicity with RLP because of the presence of the renal portal system and direct venous blood flow from the pelvic limbs to the kidneys. In a randomized, blinded, placebo-controlled study, the safety of repeated amikacin administration (20 mg/kg q24h for 3 doses) via RLP was evaluated in healthy female chickens (; n = 8 treatment, n = 8 saline control group). Plasma uric acid concentrations were not significantly elevated in treated birds compared with the control group at any time point following RLP. One week following the final RLP, birds were necropsied and the kidneys evaluated grossly and histologically. There was no significant difference in renal pathology scores between treated and control birds or between kidneys ipsilateral to the perfused limb and contralateral kidneys. This study concludes that RLP of amikacin at high doses produced no discernable renal pathology in healthy euhydrated chickens.

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Source
http://dx.doi.org/10.1647/21-00013DOI Listing

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