https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=35972795&retmode=xml&tool=Litmetric&email=readroberts32@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09 359727952023010220241218
1744-790964122022DecJournal of integrative plant biologyJ Integr Plant BiolThe chromatin remodeler BRAHMA recruits HISTONE DEACETYLASE6 to regulate root growth inhibition in response to phosphate starvation in Arabidopsis.231423262314-232610.1111/jipb.13345Plasticity in root system architecture (RSA) allows plants to adapt to changing nutritional status in the soil. Phosphorus availability is a major determinant of crop yield, and RSA remodeling is critical to increasing the efficiency of phosphorus acquisition. Although substantial progress has been made in understanding the signaling mechanism driving phosphate starvation responses in plants, whether and how epigenetic regulatory mechanisms contribute is poorly understood. Here, we report that the Switch defective/sucrose non-fermentable (SWI/SNF) ATPase BRAHMA (BRM) is involved in the local response to phosphate (Pi) starvation. The loss of BRM function induces iron (Fe) accumulation through increased LOW PHOSPHATE ROOT1 (LPR1) and LPR2 expression, reducing primary root length under Pi deficiency. We also demonstrate that BRM recruits the histone deacetylase (HDA) complex HDA6-HDC1 to facilitate histone H3 deacetylation at LPR loci, thereby negatively regulating local Pi deficiency responses. BRM is degraded under Pi deficiency conditions through the 26 S proteasome pathway, leading to increased histone H3 acetylation at the LPR loci. Collectively, our data suggest that the chromatin remodeler BRM, in concert with HDA6, negatively regulates Fe-dependent local Pi starvation responses by transcriptionally repressing the RSA-related genes LPR1 and LPR2 in Arabidopsis thaliana.© 2022 Institute of Botany, Chinese Academy of Sciences.LiTaoTShanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 201602, China.University of Chinese Academy of Sciences, Beijing, 100049, China.ZhangRuyueRShanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 201602, China.University of Chinese Academy of Sciences, Beijing, 100049, China.SatheeshViswanathanVShanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 201602, China.WangPengPShanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 201602, China.MaGuojieGShanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 201602, China.GuoJianfeiJShanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 201602, China.AnGuo-YongGYState Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng, 475004, China.LeiMingguangMShanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 201602, China.State Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng, 475004, China.engNatural Science Foundation of Shanghai22ZR1469200Natural Science Foundation of ShanghaiJournal Article20220923
China (Republic : 1949- )J Integr Plant Biol1012505021672-90720Histones0Chromatin0Phosphates0Arabidopsis Proteins27YLU75U4WPhosphorusEC 3.5.1.-HDA6 protein, ArabidopsisEC 3.5.1.98Histone DeacetylasesEC 3.6.1.3BRM protein, ArabidopsisEC 3.6.1.-Adenosine TriphosphatasesIMArabidopsismetabolismHistonesmetabolismChromatinmetabolismPhosphatesmetabolismArabidopsis ProteinsgeneticsmetabolismPhosphorusmetabolismGene Expression Regulation, PlantHistone DeacetylasesmetabolismAdenosine TriphosphatasesgeneticsmetabolismBRMhistone deacetylationphosphate starvationroot development.202252520228142022817602023136020228161154ppublish3597279510.1111/jipb.13345REFERENCESAbel, S. (2011). Phosphate sensing in root development. Curr. Opin. 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