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pH-controlled regioselective nucleophilic ring-opening of epoxide: an improved process for the preparation of ()-(-)- or ()-(+)-3-hydroxytetrahydrofuran. | LitMetric
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pH-controlled regioselective nucleophilic ring-opening of epoxide: an improved process for the preparation of ()-(-)- or ()-(+)-3-hydroxytetrahydrofuran.

Ankita Chakraborty Avula Shiva Krishna Gurrala Sheelu Subhash Ghosh Thenkrishnan Kumaraguru

Org Biomol Chem

Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.

Published: August 2022

An environmentally benign, cost-effective and scalable process for the preparation of both the enantiomers of 3-hydroxytetrahydrofuran has been developed. pH-Controlled ring opening of enantiomerically pure epichlorohydrins with cyanohydrin is the key step of the process. The entire protocol does not require any column purification.

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 Source
http://dx.doi.org/10.1039/d2ob01314bDOI Listing

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