AI Article Synopsis
- Age-related macular degeneration (AMD), diabetic retinopathy, and retinal vein occlusion are major causes of vision impairment in developed countries.
- The treatment for these conditions typically involves intravitreal injections of anti-VEGF agents, with brolucizumab being a recently approved option specifically for neovascular AMD.
- Brolucizumab may reduce the number of clinic visits needed for treatment while maintaining effectiveness, and the review focuses on its pharmacological properties and the outcomes from key clinical trials related to its safety and efficacy.
Article Abstract
Age-related macular degeneration (AMD), diabetic retinopathy and retinal vein occlusion represent some of the commonest degenerative conditions that lead to severe vision impairment in the developed countries. The gold standard treatment of complications associated with these conditions is the intravitreal administration of anti-vascular endothelial growth factor (VEGF) agents. Brolucizumab is a newly developed, humanised, single-chain fragment of a monoclonal antibody binding all VEGF-A isoforms, which was recently approved for the treatment of neovascular AMD. Intravitreal brolucizumab promises to reduce treatment burden for nAMD patients by achieving comparable therapeutic outcomes with fewer clinic visits. Promising also appears its use for the treatment of more challenging maculopathies like diabetic macular oedema (DMO). The aim of this review is to describe the special pharmacological properties of brolucizumab and display the outcomes of the most important clinical trials and real-world studies regarding its efficacy and safety for the management of degenerative macular disorders.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375562 | PMC |
| http://dx.doi.org/10.2147/DDDT.S378450 | DOI Listing |
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