AI Article Synopsis
- - This review examines the use of excited state meta effect (ESME) in creating photolabile protecting groups (PPGs), which help release different functional groups.
- - It highlights the benefits of ESME-based PPGs, showcasing their ability to efficiently release challenging leaving groups like hydroxyl and amino directly.
- - The applications of these PPGs span various fields, including synthesis, the release of biologically important molecules, materials science, and biomedical engineering.
Article Abstract
This review focuses on utilization of the excited state meta effect (ESME) in the development of photolabile protecting groups (PPGs). Structurally simple ESME-based PPGs for release of various functional groups (such as carbonyl, hydroxyl, carboxyl, amino and thiol groups) are discussed. Examples that demonstrate the appealing advantages of these new PPGs are provided, including their efficient release of "poor" leaving groups such as hydroxyl or amino group directly instead of in their respective carbonate or carbamate form. Applications of these PPGs in synthesis, release of biologically important molecules, materials science and biomedical engineering are also described.
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