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Submicron ultrasound contrast agents hold great potential to extend the bubble-mediated theranostics beyond the vasculature, but their acoustic response and the interaction effects between them remain poorly understood. This study set out to numerically examine the interaction effects on the subharmonic oscillations of nanobubbles and the resultant acoustic emissions under subharmonic resonance conditions. Results showed that a negative correlation between bubble size and subharmonic resonance frequency is readily obtained from the radius response curves.

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