Capacity of species to produce acetaldehyde at various concentrations of alcohol.

Background: Along with tobacco use, alcohol consumption is one of the crucial factors for oral cancer. Acetaldehyde (ACH), a byproduct of alcohol, is reported as carcinogenic. One of the producers of ACH from alcohol is Candida species. The aim of the study was to quantify the ACH produced by species at various concentrations of alcohol.

Materials And Methods: Clinical isolates of , namely , and and ATCC 18,804, were subjected to various concentrations of alcohol. Alcohol dehydrogenase and ACH were estimated using spectrophotometry and headspace gas chromatography, respectively.

Results: Out of all three clinical isolates, produced more ACH (412.1 μM) at 10 mM alcohol concentration by 10colony-forming unit/ml followed by (233 μM) and (53.7 μM). of clinical isolate and ATCC species (222 μM) did not show much difference.

Conclusion: The study results conclude that species are capable of producing carcinogenic levels of ACH on exposure to various concentrations of alcohol.