AI Article Synopsis
- Researchers have focused on the detection of antiviral drugs for COVID-19, particularly those targeting SARS-CoV-2, like chloroquine, ritonavir, and indomethacin.
- Cuttlefish bone powder (CFBP) has been successfully used for the first time as a solid-phase extraction sorbent to extract these antiviral drugs from water samples.
- The study developed a method combining CFBP, optimized through experimental design, which demonstrated high extraction recovery rates and low detection limits for the antiviral drugs.
Article Abstract
Many antiviral drugs were developed to counteract coronavirus disease, 2019 (COVID-19) with severe acute respiratory syndrome. Therefore, the scientific community's efforts have focused on the detection and quantification of antiviral compounds currently being tested for COVID-19 treatment. Cuttlefish bone powder (CFBP) has been used for the first time as solid-phase extraction (SPE) sorbent for the extraction of SARS CoV-2 antiviral drugs (chloroquine, ritonavir and indomethacin) from water samples. An effective and sensitive method was developed by combining SPE and liquid chromatography- UV detection (LC-UV). An experimental design was applied for the optimization of extraction process. Experimental variables were optimized using Doehlert matrix. The developed method included 50 mg of CFBP sorbent, 20 mL of water sample at pH = 9 and 5 mL of ACN/KHPO buffer solution (80:20, v/v) in the elution step. For validation of the method, selectivity, linearity precision, and sensitivity were evaluated. Extraction recovery percentage of all Sars cov-2 antivirals were above 98.2%. The detection and quantification limits were between 0.1 and 0.5 µg L and 0.6 and 2 µg L, respectively. The current study suggested that CFBP has the application potential for the enhanced SPE of SARS CoV-2 antiviral drugs from water samples.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9362547 | PMC |
| http://dx.doi.org/10.1007/s11696-022-02388-6 | DOI Listing |
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