AI Article Synopsis
- A 13-year-old girl with acute focal bacterial nephritis, caused by a methicillin-resistant Gram-positive bacterium, experienced symptoms like fever and abdominal pain after being treated for a urinary tract infection.
- Initially started on cefotaxime, she was later switched from vancomycin to daptomycin after developing an allergy.
- Daptomycin proved effective, leading to no adverse events or relapse, highlighting it as a potential alternative treatment for children unable to use vancomycin.
Article Abstract
is a gram-positive, coagulase-negative member of the genus and is second only to as a cause of urinary tract infections in the young female population. usually has good susceptibility to drugs commonly used to treat urinary tract infections, but it is often methicillin-resistant. Here we report a case of acute focal bacterial nephritis in a 13-year-old female patient caused by methicillin-resistant and treated with daptomycin (DAP). The patient had a history of unilateral hearing loss and presented to her previous physician with a 3-day history of fever, right-sided abdominal pain, and diarrhea. Cefotaxime antimicrobial chemotherapy was initiated as an empiric therapy targeting the most frequent cause of community-onset pyelonephritis. Vancomycin (VCM) was started for acute focal bacterial nephritis caused by methicillin-resistant but was stopped due to allergy and replaced with DAP. After 13 days of treatment with DAP, the patient received 17 days of treatment with sulfamethoxazole-trimethoprim combination therapy. The patient experienced no adverse events and did not relapse. DAP is a relatively new anti-methicillin-resistant drug used to treat gram-positive cocci infections. It is primarily excreted by the kidneys, which may be desirable in treating urinary tract infections. For children who cannot receive VCM for any reason, DAP may be a viable alternative.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372729 | PMC |
| http://dx.doi.org/10.1016/j.idcr.2022.e01594 | DOI Listing |
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