Gamma oscillation is the synchronization with a frequency of 30-90 Hz of neural oscillations, which are rhythmic electric processes of neuron groups in the brain. The inhibitory interneuron network is necessary for the production of gamma oscillations, but certain disruptions such as brain inflammation, oxidative stress, and metabolic imbalances can cause this network to malfunction. Gamma oscillations specifically control the connectivity between different brain regions, which is crucial for perception, movement, memory, and emotion. Studies have linked abnormal gamma oscillations to conditions of the central nervous system, including Alzheimer's disease, Parkinson's disease, and schizophrenia. Evidence suggests that gamma entrainment using sensory stimuli (GENUS) provides significant neuroprotection. This review discusses the function of gamma oscillations in advanced brain activities from both a physiological and pathological standpoint, and it emphasizes gamma entrainment as a potential therapeutic approach for a range of neuropsychiatric diseases.
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| http://dx.doi.org/10.3389/fncel.2022.962957 | DOI Listing |
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- The study investigates the effect of 40-Hz audiovisual stimulation on seizure susceptibility and amyloid-beta plaque levels in 5xFAD mice, a model for Alzheimer's disease.
- Results showed that this sensory stimulation decreased seizure severity and delayed epileptogenesis, with 5xFAD mice experiencing about a 50% reduction in amyloid pathology compared to those without stimulation.
- The findings suggest that 40-Hz stimulation may benefit both the reduction of Aβ pathology and possibly influence glial cells, impacting seizure activity, even in mice without amyloid plaques.
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