Investigation on Probable Association Between , and Genes Polymorphism and Pulmonary Tuberculosis.

Objective: Our study aimed to explore the association of , and genes polymorphisms with PTB susceptibility and its clinical features.

Methods: Nine SNPs were genotyped by improved multiple ligase detection reaction (iMLDR) in 476 PTB patients and 473 controls. The association between these SNPs and PTB risk was analyzed using SPSS software and haplotype analysis was assessed using SHEsis software.

Results: The rs2495636 GA genotype frequency in PTB patients was significantly decreased, and rs5946039 A allele was related to the lower risk of PTB. In gene, rs20541 variant was found to be associated with PTB risk under recessive mode. Moreover, rs141573089 C allele was significantly lower in PTB presenting with fever, drug resistance, and CC genotype was decreased in PTB presenting with leukopenia. rs2495636 polymorphism was associated with drug resistance, pulmonary infection, and rs3795175, rs638376 polymorphisms were related to drug resistance in PTB patients.

Conclusion: rs20541, rs2495636, rs5946039 polymorphisms might be contributed to the genetic background of PTB in Chinese population.