A robust [C]acetate synthesis on a TRACERLab FX C pro module.

Appl Radiat Isot

Interdisciplinary PET Center, Department of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacher Strasse 6, 97080, Würzburg, Germany.

Published: October 2022

Carbon-11 labelled acetate ([C]acetate) is a radiotracer of importance in clinical practice as well as in preclinical research. The TRACERLab FX C Pro Synthesizer can be used this sensitive carboxylation reaction. Starting from 11 GBq [C]CO, we were able to isolate about 3 GBq [C]acetate after only 20 min reaction time (yield 56 ± 7%, n = 10).

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http://dx.doi.org/10.1016/j.apradiso.2022.110356DOI Listing

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