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| http://dx.doi.org/10.1016/j.jaad.2022.07.058 | DOI Listing |
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Article Synopsis
- Superficial malignant peripheral nerve sheath tumors (SF-MPNSTs) are rare cancers that share some features with spindle cell melanomas and desmoplastic melanomas, but their biological characteristics remain poorly understood.* -
- A study comparing SF-MPNST to other tumor types through whole-exome and RNA sequencing found that SF-MPNST had an intermediate tumor mutational burden and distinct gene expression patterns, indicating differences among these cancer types.* -
- Immunohistochemical analysis revealed notable differences in markers like H3K27me3 and PRAME between SF-MPNST and other cancers, suggesting potential for new diagnostic markers and insights into tumor behavior.*
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