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Exhaled Breath Analysis Using a Novel Electronic Nose for Different Respiratory Disease Entities.
Lung
January 2025
Department of Internal Medicine, National Taiwan University Hospital, No.7, Chung Shan S. Rd., Zhongzheng District, Taipei City, 100225, Taiwan.
Purpose: Electronic noses (eNose) and gas chromatography mass spectrometry (GC-MS) are two important breath analysis approaches for differentiating between respiratory diseases. We evaluated the performance of a novel electronic nose for different respiratory diseases, and exhaled breath samples from patients were analyzed by GC-MS.
Materials And Methods: Patients with lung cancer, pneumonia, structural lung diseases, and healthy controls were recruited (May 2019-July 2022).
A handheld biofluorometric system for acetone detection in exhaled breath condensates.
Analyst
January 2025
Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
As a marker of human metabolism, acetone is important for lipid metabolism monitoring and early detection of diabetes. In this study, we developed a handheld biosensor for acetone based on fluorescence detection by utilizing the enzymatic reaction of secondary alcohol dehydrogenase (S-ADH) with β-nicotinamide adenine dinucleotide (NADH, = 340 nm, = 490 nm). In the reaction, NADH is oxidized when acetone is reduced to 2-propanol by S-ADH, and the acetone concentration can be measured by detecting the amount of NADH consumed in this reaction.
View Article and Find Full Text PDFQuartz-Enhanced Photoacoustic Spectroscopy-Based Acetone and Ammonia Measurements from Human Breath Near 8 μm Wavelength Band.
ACS Sens
January 2025
Department of Engineering Design, Indian Institute of Technology Madras, Chennai 600036, India.
Human breath gas analysis is a noninvasive disease diagnostic approach used to identify different pathological conditions in the human body. Monitoring breath acetone (CHO) and ammonia (NH) as biomarkers is vital in diagnosing diabetes mellitus and liver disorders, respectively. In this article, the quartz-enhanced photoacoustic spectroscopy (QEPAS) technique is proposed and demonstrated for measuring CHO and NH in human exhaled breath samples.
View Article and Find Full Text PDFA Doped Surface Ionization Method for Ion Mobility Spectrometry.
Rapid Commun Mass Spectrom
March 2025
State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China.
Rationale: Exhaled breath can be used for early warning of disease, with organic nitrogen compounds, including triethylamine (TEA), being linked to various medical conditions. Surface ionization ion mobility spectrometry (SI-IMS) facilitates the direct detection of TEA in exhaled breath. However, the presence of multiple ionization products of TEA poses challenges for both quantitative and qualitative analyses.
View Article and Find Full Text PDFRational Design and Application of Breath Sensors for Healthcare Monitoring.
ACS Sens
December 2024
Department of Hepatology, Beijing Ditan Hospital of Capital Medical University, 100015Beijing, PR China.
Biomarkers contained in human exhaled breath are closely related to certain diseases. As a noninvasive, portable, and efficient health diagnosis method, the breath sensor has received considerable attention in recent years for early disease screening and prevention due to its user-friendly and easy-accessible features. Although some key challenges have been addressed, its capability to precisely monitor specific biomarkers of interest and its physiological relevance to health metrics is still to be ascertained.
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