THE STATE OF TOXIN-RELEASING FUNCTION OF THE KIDNEYS IN THE SYNDROME OF ENDOGENOUS INTOXICATION OF PURULENT-SEPTIC ORIGIN IN PATIENTS WITH DIABETES MELLITUS.

Objective: The aim: To investigate the state of renal toxin excretory function in EIS of purulent-septic genesis in patients with diabetes mellitus-2 under the condition of infusion load with low-volume Ringer's solution.

Patients And Methods: Materials and methods: The research belongs to the opened, randomized, prospective and controlled studies. The study group was consisted of patients with diabetes mellitus-2 complicated syndrome of endogenous intoxication of purulent-septic origin (CDSEI).

Results: Results: However, their activity is different. In particular, renal toxin excretory function in patients with CDSEI by STPC clearance is characterized by an increase in activity by 165% (control - 282%; p <0.05), and by MMM clearance - by 137% (control - 171%; p <0.05). These data indicate the degree of depression of renal toxin function in patients with CDSEI and its compensatory capabilities.

Conclusion: Conclusions: The depression of the clearance of total blood plasma toxicity is a predictor of the predominance of toxin formation over the elimination of toxic substances in patients with diabetes mellitus 2 complicated by purulent-septic pathology. The low-volume infusion loads with Ringer's solution in terms of clearance of total blood plasma toxicity is a sensitive indicator of the degree of depression of toxin-releasing function of the kidneys and compensatory capabilities in diabetes mellitus 2 complicated by purulent-septic pathology.