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Exploring the binomial BALB/c-Leishmania (Viannia) braziliensis model to assess the in vivo performance of Thor strain subpopulations.
Exp Parasitol
December 2024
Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Biologia Molecular e Doenças Endêmicas, Rio de Janeiro, RJ, Brazil. Electronic address:
Article Synopsis
- Leishmania (Viannia) braziliensis causes various types of leishmaniasis, and the study investigates how different subpopulations (Thor03, Thor10, Thor22) affect disease progression in BALB/c mice.
- The research found that after three weeks of infection, Thor03 and Thor10 led to larger lesions and influenced immune response markers, showing lower IL-12 and TNF levels, while Thor10 had the highest IL-10 levels.
- The study concluded that these subpopulations might lead to mild footpad lesions but can persist in lymph nodes, highlighting differences in infection patterns and immune responses among the subpopulations.
Cutaneous Findings as a Harbinger of Disseminated Fungal Infection.
Cureus
November 2024
Department of Dermatology, University of Nebraska Medical Center, Omaha, USA.
is a dimorphic fungus that causes pulmonary, disseminated, or, rarely, primary cutaneous disease. Primary cutaneous histoplasmosis presents with non-specific skin lesions, which can lead to poor patient outcomes due to diagnostic challenges and delays in diagnosis. A 62-year-old male on immunosuppressive medications for lupus nephritis presented to the emergency department with 24 hours of altered mental status.
View Article and Find Full Text PDFCutaneous ulcers in sarcoidosis.
Dermatol Online J
August 2024
Dermatology Department of Medicine, King Abdulaziz Medical City (KAMC) Ministry of National Guard, Western region, Jeddah, Kingdom of Saudi Arabia.
Sarcoidosis is a disease characterized by immunological granuloma formation in various organs. Cutaneous manifestations occur in about 25% of patients with rare cases showing ulcerative sarcoidosis, that can be debilitating if not treated promptly. This article presents a patient with isolated ulcerative sarcoidosis and reviews existing literature.
View Article and Find Full Text PDFAddressing Diagnostic Challenges in Livedoid Vasculopathy: A Case Report on Interdisciplinary Management.
Cureus
October 2024
Internal Medicine, Veterans Affairs Caribbean Healthcare System, San Juan, PRI.
Livedoid vasculopathy (LV) is a rare vascular disorder characterized by excessive thrombosis of cutaneous vasculature, leading to dermal vessel occlusion, skin hypoxia, and ulceration. The nonspecific nature of its clinical manifestations often complicates diagnosis and inadequate oxygenation results in lesions that take longer to heal and are more susceptible to infections and complications. Despite its impact on patient quality of life, LV remains largely undocumented in the literature, making effective management challenging.
View Article and Find Full Text PDFOdontogenic Cutaneous Sinus Tract in a 12-Year-Old Patient: Case Report.
Pediatr Dermatol
November 2024
Department of Oral and Dental Pathology, Faculty of Odontology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
An odontogenic cutaneous sinus tract is considered an uncommon skin lesion resulting from a dental infection. In most cases of periapical abscesses, the sinus tract emerges intraorally, but rarely may appear on the cutaneous surface. The nonspecific clinical symptoms and diverse appearance of such lesions can lead to misdiagnosis and mistreatment of patients.
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