FTO, as an mA mRNA demethylase, is involved in various cancers. However, the role of FTO in clear cell renal cell carcinoma (ccRCC) remains unclear. In the present study, we discovered FTO is upregulated in ccRCC. Functionally, knockdown of FTO significantly impairs the proliferation and migration ability of ccRCC cells. Mechanistically, our data suggest FTO promotes the proliferation and migration of ccRCC through preventing degradation of PDK1 mRNA induced by YTHDF2 in an mA-dependent mechanism. Overall, our results identify the protumorigenic role of FTO through the mA/YTHDF2/PDK1 pathway, which could be a promising therapeutic target for ccRCC.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374762 | PMC |
| http://dx.doi.org/10.1038/s41420-022-01151-w | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
m6A demethylation of NNMT in CAFs promotes gastric cancer progression by enhancing macrophage M2 polarization.
Cancer Lett
December 2024
Digestive Diseases Center, Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, 518107, China. Electronic address:
Cancer associated fibroblasts (CAFs) are the predominant stromal cells in the tumor microenvironment of gastric cancer (GC), interacting with both immune and tumor cells to drive cancer progression. However, the precise link between these interactions and their potential as therapeutic targets remains poorly understood. In this study, we identified for the first time that nicotinamide N-methyltransferase (NNMT) derived from CAFs promoted M2 macrophage polarization, which, in turn, facilitated the proliferation and migration of GC cells.
View Article and Find Full Text PDFFTO activates PD-L1 promotes immunosuppression in breast cancer via the m6A/YTHDF3/PDK1 axis under hypoxic conditions.
J Adv Res
December 2024
Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin 150040, China; Lead Contact. Electronic address:
Introduction: Altered epigenetic reprogramming enables breast cancer cells to adapt to hypoxic stress. Hypoxic microenvironment can alter immune cell infiltration and function, limiting the effectiveness of immunotherapy.
Objectives: The study aimed to identify how fat mass and obesity-associated protein (FTO) helps breast cancer cells cope with the hypoxic microenvironment and the mechanisms behind breast cancer cell resistance to tumor immunity.
FTO Facilitates Cervical Cancer Malignancy Through Inducing m6A-Demethylation of PIK3R3 mRNA.
Cancer Med
December 2024
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Background: The incidence rate and mortality of cervical cancer rank the fourth in the global female cancer. N6-methyladenosine (m6A) always plays an important role in tumor progression, and fat mass and obesity-associated gene (FTO) works as the m6A demethylase.
Aims: Our study aimed to narrate the biological function and potential mechanisms for FTO in cervical cancer malignancy.
Boosting Efficiency in Carbon Nanotube-Integrated Perovskite Photovoltaics.
Langmuir
December 2024
Department of Geophysics, College of Remote Sensing and Geophysics, Al-Karkh University of Science, Baghdad 10011, Iraq.
Carbon nanomaterials (graphene, carbon nanotubes, and graphene oxide) have potential applications for optoelectronics, thanks to their superior electronic and optical characteristics. The remarkable stability of carbon-based perovskite solar cells (PSCs) has attracted significant attention. Herein, a fluorine-doped carbon nanotube (F-CNT) is incorporated into the PSCs as a hole-transporting layer (HTL) in between methylammonium lead iodide (MAPbI) and the rear electrode to develop an effective MAPbI/HTL interface.
View Article and Find Full Text PDF3,6-Bis(methylthio)-9H-carbazole Based Self-Assembled Monolayer for Highly Efficient and Stable Inverted Perovskite Solar Cells.
Angew Chem Int Ed Engl
December 2024
Ulsan National Institute of Science and Technology, School of Energy and Chemical Engineering & Graduate School of Carbon Neutrality, KOREA, REPUBLIC OF.
The photovoltaic performance of inverted perovskite solar cells (PSCs) relies on effectively managing the interface between the hole extraction layer and the light-absorbing perovskite layer. In this study, we have synthesised (4-(3,6-bis(methylthio)-9H-carbazol-9-yl)butyl)phosphonic acid (MeS-4PACz), which forms a self-assembled monolayer on the fluorine-doped tin oxide (FTO) electrode. The molecule's methylthio substituents generate a favourable interfacial dipole moment and interact with the perovskite layer.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!