AI Article Synopsis
- Ganoderma lucidum is an edible mushroom that's also used for medicine.
- Researchers found 29 special compounds in it, including 11 new ones, which can help with health.
- These compounds may reduce inflammation in the brain and don't harm cancer cells, making the mushroom useful for food or medicine.
Article Abstract
Ganoderma lucidum is a famous edible and medicinal fungus. Through a bioactive phytochemical investigation of the ethanolic extracts of the fruiting bodies of G. lucidum, twenty-nine triterpenoids, including eleven previously undescribed triterpenoids, were isolated and characterized based on spectroscopic data. The inhibitory effects of all the triterpenes against fatty acid amide hydrolase (FAAH) were found to be in the range of 30-60% at 100 μM. Methyl ganoderate A displayed the strongest inhibitory activity (61%) against FAAH. Furthermore, all compounds displayed no cytotoxicity against LOVO and MCF-7 human cancer cells. Hence, our present study provides information about G. lucidum as a functional food or pharmaceutical supplement for the treatment of neuroinflammation.
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| http://dx.doi.org/10.1016/j.phytochem.2022.113339 | DOI Listing |
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