AI Article Synopsis
- * The study aimed to investigate if inflammation linked to WMH could influence the inflammatory response in patients experiencing acute ischemic stroke (AIS).
- * Among 149 AIS patients, 38.3% had a high WMH burden, but the initial association between WMH and specific inflammatory markers did not hold true after further analysis.
Article Abstract
Inflammation is involved in small vessel disease (SVD). We aim to clarify whether inflammation related to white matter hyperintensities (WMH), a key component of SVD, may affect the inflammatory response in acute ischemic stroke (AIS) patients. For this, we sequentially measured 10 circulating inflammatory markers and assessed WMH burden on admission MRI in AIS patients treated with thrombectomy. Of 149 patients, 57 (38.3%) had a high WMH burden (Fazekas≥3). A high WMH burden was associated with 4 markers levels but this association did not remain following multivariable analyses. WMH burden is not associated with a specific inflammatory profile in AIS.
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| http://dx.doi.org/10.1016/j.jneuroim.2022.577934 | DOI Listing |
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