Objective: Recently, the possibility that oral microbiomes is associated with oral squamous cell carcinoma (OSCC) initiation and progression has attracted attention; however, this association is still unclear. Here, we comprehensively analyze the microbiome profiles of saliva samples using next-generation sequencing followed by determining the association between oral microbiome profiles and OSCC.
Materials And Methods: Microbiome profiles in saliva samples from patients with OSCC, oral leukoplakia (OLK), and postoperative OSCC (Post) were analyzed. Candidate OSCC-associated bacteria were identified by comparing the bacterial diversity and relative abundance of each group based on these microbiome profiles, and their applicability as OSCC detection tools were evaluated.
Results: There were significant differences in genus abundances (, and ) among the groups from saliva samples. In the OSCC group, compared with the OLK and Post groups, abundances of the genus , phylum and phylum were markedly increased and that of the genus and phylum were decreased.
Conclusion: The results suggested a strong association of these bacteria with OSCC. Especially, phylum was significantly associated with early recurrence of OSCC. Thus, oral microbiome analysis may have a potential of novel OSCC detection and prognostic tool.
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| http://dx.doi.org/10.1080/20002297.2022.2105574 | DOI Listing |
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