AI Article Synopsis
- Matrine, a natural pesticide, is used widely in agriculture due to its effective biological activity.
- By adding halopyrazole groups to matrine, eight new compounds were created, achieving a yield of 78-87%.
- These new derivatives showed significantly increased insecticidal and fungicidal activities, with one compound, 4-Cl-Pyr-Mat, demonstrating inhibition rates 23-33% higher than matrine.
Article Abstract
Matrine is a traditional botanical pesticide with a broad-spectrum biological activity that is widely applied in agriculture. Halopyrazole groups are successfully introduced to the C13 of matrine to synthesize eight new derivatives with a yield of 78-87%. The insecticidal activity results show that the introduction of halopyrazole groups can significantly improve the insecticidal activity of matrine on , and with a corrected mortality rate of 100%, which is 25-65% higher than matrine. The fungicidal activity results indicate that derivatives have a high inhibitory effect on , , and . Thereinto, 4-Cl-Pyr-Mat has the best result, with an inhibition rate of 23-33% higher than that of matrine. Therefore, the introduction of halogenated pyrazole groups can improve the agricultural activity of matrine.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370413 | PMC |
| http://dx.doi.org/10.3390/molecules27154974 | DOI Listing |
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