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Supplementation of Polysaccharide Combined with Aerobic Exercise Ameliorates High-Fat-Induced Nonalcoholic Steatohepatitis via AMPK/PPARα/PGC-1α Pathway. | LitMetric

AI Article Synopsis

  • * Researchers tested LBP, AE, and a combination of both over 10 weeks on rats with high-fat-induced NASH, finding that both LBP and AE individually reduced NASH severity.
  • * The combination of LBP and AE was even more effective, improving liver damage and lowering inflammation and fat levels, by activating a pathway that enhances fatty acid oxidation.

Article Abstract

Nonalcoholic steatohepatitis (NASH) is a subtype of nonalcoholic fatty liver disease (NAFLD). Either polysaccharide (LBP) or aerobic exercise (AE) has been reported to be beneficial to hepatic lipid metabolism. However, whether the combination of LBP with AE improves lipid accumulation of NASH remains unknown. Our study investigated the influence of 10 weeks of treatment of LBP, AE, and the combination (LBP plus AE) on high-fat-induced NASH in Sprague-Dawley rats. The results showed that LBP or AE reduced the severity of the NASH. LBP plus AE treatment more effectively ameliorated liver damage and lowered levels of serum lipid and inflammation. In addition, the combination can also regulate genes involved in hepatic fatty acid synthesis and oxidation. LBP plus AE activated AMPK, thereby increasing the expression of PPARα which controls hepatic fatty acid oxidation and its coactivator PGC-1α. Our study demonstrated the improvement of LBP plus AE on NASH via enhancing fatty acid oxidation (FAO) which was dependent on AMPK/PPARα/PGC-1α pathway.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370707PMC
http://dx.doi.org/10.3390/nu14153247DOI Listing

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