AI Article Synopsis
- A specific gene was found to be significantly overexpressed in pre-eclamptic placentas, suggesting its potential role in the disease's development.
- Researchers used RNA sequencing to analyze placental expression in women with pre-eclampsia versus those with healthy pregnancies, discovering a linked long non-coding RNA (lncRNA) gene nearby the overexpressed gene.
- While the lncRNA's expression did not influence the overexpressed gene's levels, its transcript was related to birth and placental weights, indicating it may play a crucial role in the mechanisms of pre-eclampsia.
Article Abstract
Background: is one of the significantly overexpressed genes found in a pre-eclamptic placenta and is involved with the etiology of this disease.
Methods: We conducted genome-wide expression profiling by RNA-seq of placentas from women with pre-eclampsia and those with normotensive pregnancy.
Results: We identified a lncRNA gene, , located ~80 kb upstream of the gene in a head-to-head orientation, which was overexpressed in the pre-eclamptic placenta. and are located within the same topologically associated domain in the genome. The mRNA level correlated with that of the in placentas from pre-eclamptic women as well as in samples from uncomplicated pregnancies. However, neither the overexpression nor knockdown of affected the expression of . Analysis of pre-eclampsia-linking genetic variants at this locus suggested that the placental genotype of one variant was associated with the expression of . The transcript level was not found to be associated with maternal blood pressure, but showed a relationship with birth and placental weights, suggesting that this lncRNA might be one of the pivotal placental factors in pre-eclampsia.
Conclusion: Further characterization of the gene may elucidate the etiological roles of the and genes in pre-eclampsia in a genomic context.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369602 | PMC |
| http://dx.doi.org/10.3390/jcm11154603 | DOI Listing |
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