AI Article Synopsis

  • Identifying effective anti-aging compounds is crucial for research on longevity and skin health, focusing on nutrient signaling regulators like metformin, resveratrol, and rapamycin, although their effects on skin aging are debated.
  • A study tested the combined effects of triacetylresveratrol and cannabidiol on skin fibroblasts, revealing that this combination significantly improved cell viability, wound healing, and reduced metabolic dysfunction.
  • In contrast, metformin showed no positive effects, and rapamycin negatively impacted cell viability and wound healing speed, suggesting the need for further animal studies to explore the benefits of using triacetylresveratrol with cannabidiol in anti-aging treatments.

Article Abstract

Identifying effective anti-aging compounds is a cornerstone of modern longevity, aging, and skin-health research. There is considerable evidence of the effectiveness of nutrient signaling regulators such as metformin, resveratrol, and rapamycin in longevity and anti-aging studies; however, their potential protective role in skin aging is controversial. In light of the increasing appearance of phytocannabinoids in beauty products without rigorous research on their rejuvenation efficacy, we decided to investigate the potential role of phytocannabinoids in combination with nutrient signaling regulators in skin rejuvenation. Utilizing CCD-1064Sk skin fibroblasts, the effect of metformin, triacetylresveratrol, and rapamycin combined with phytocannabinoids on cellular viability, functional activity, metabolic function, and nuclear architecture was tested. We found triacetylresveratrol combined with cannabidiol increased the viability of skin fibroblasts (p < 0.0001), restored wound-healing functional activity (p < 0.001), reduced metabolic dysfunction, and ameliorated nuclear eccentricity and circularity in senescent fibroblasts (p < 0.01). Conversely, metformin with or without phytocannabinoids did not show any beneficial effects on functional activity, while rapamycin inhibited cell viability (p < 0.01) and the speed of wound healing (p < 0.001). Therefore, triacetylresveratrol and cannabidiol can be a valuable source of biologically active substances used in aging and more studies using animals to confirm the efficacy of cannabidiol combined with triacetylresveratrol should be performed.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368899PMC
http://dx.doi.org/10.3390/ijms23158804DOI Listing

Publication Analysis

Top Keywords

nutrient signaling
12
signaling regulators
12
functional activity
12
skin fibroblasts
8
phytocannabinoids
5
effects nutrient
4
regulators combination
4
combination phytocannabinoids
4
phytocannabinoids senescence-associated
4
senescence-associated phenotype
4

Similar Publications

Unlabelled: Many bacteria metabolize ethanolamine as a nutrient source through cytoplasmic organelles named bacterial microcompartments (BMCs). Here we investigated the molecular assembly, regulation, and function of BMCs in a Gram-negative oral pathobiont that is associated with adverse pregnancy outcomes. The genome harbors a conserved ethanolamine utilization () locus with 21 genes that encode several putative BMC shell proteins and a two-component signal transduction system (TCS), in addition to the enzymes for ethanolamine transport and catabolism.

View Article and Find Full Text PDF

Agastache rugosa, a perennial herb native to temperate and subtropical regions, shows remarkable adaptive strategies when exposed to varying light and nutrient conditions in tropical environments. Our study reveals new insights into the crosstalk mechanisms involving carbohydrate homeostasis, biomass allocation, and nutrient acquisition in A. rugosa under different environmental conditions.

View Article and Find Full Text PDF

Transcriptomic and physiological analyses reveal the toxic effects of inorganic filters (nZnO and nTiO) on scleractinian coral Galaxea fascicularis.

Environ Res

December 2024

Guangxi Laboratory on the Study of Coral Reefs in the South China Sea, Coral Reef Research Center of China, School of Marine Sciences, Guangxi University, Nanning 530004, China.

The effects of sunscreen on scleractinian corals have garnered widespread attention; however, the toxic effects and mechanisms remain unclear. This study investigated the toxicological effects of two common inorganic filters used in sunscreens, nano zinc oxide and titanium dioxide (nZnO and nTiO₂), on the reef-building coral Galaxea fascicularis, focusing on the phenotypic, physiological, and transcriptomic responses. The results showed that after exposure to 0.

View Article and Find Full Text PDF

Brain endocannabinoid control of metabolic and non-metabolic feeding behaviors.

Neurochem Int

December 2024

Basic School of Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 260071, China. Electronic address:

The central endocannabinoid (eCB) system in brain shows a crucial role in the regulation of feeding behaviors, influencing both metabolic and non-metabolic mechanisms of appetite control, which has been paid much attention. Although there are already many review articles discussing eCB modulation of feeding behaviors, our paper attempts to summarize the recent advancements through synapses, circuits, and network in brain. Our focus is on the dual role of eCB signalling in regulating metabolic energy balance and hedonic reward-related feeding.

View Article and Find Full Text PDF

Isotopes unveil overestimation of nutrient-driven oxygen deficit in the tidal rivers of Pearl River Delta during the wet season.

Sci Total Environ

December 2024

The Key Laboratory of Water and Air Pollution Control of Guangdong Province, South China Institute of Environmental Sciences, Ministry of Ecology and Environment, Guangzhou 510530, China; National Key Laboratory of Water Environment Simulation and Pollution Control, South China Institute of Environmental Science, Ministry of Ecology and Environment, Guangzhou 510535, China. Electronic address:

A low dissolved oxygen (DO) concentration in summer has been observed in river-estuary systems worldwide. Many studies have caused our stereotype that biochemical oxygen depletion was higher in summer than in winter; however, there was no direct evidence particularly in the tidal river with complex hydrological and biochemical processes. This study employed natural-abundance and labeled isotopes to quantify seasonal apportionment of biochemical oxygen depletion.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: