Clinical Perspectives of Non-Coding RNA in Oral Inflammatory Diseases and Neuropathic Pain: A Narrative Review.

Int J Mol Sci

Department of Radiobiology and Molecular Genetics, Vinča Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.

Published: July 2022

AI Article Synopsis

  • Non-coding RNAs (ncRNAs) are crucial for regulating genes and are linked to various diseases, particularly oral inflammatory conditions.
  • The review discusses how ncRNAs could be valuable as salivary biomarkers and their roles in neuropathic pain and tissue healing.
  • It emphasizes the potential uses of ncRNAs in clinical settings, focusing on salivary diagnostics, regenerative dentistry, and personalized treatment for orofacial pain.

Article Abstract

Non-coding RNAs (ncRNAs) represent a research hotspot by playing a key role in epigenetic and transcriptional regulation of diverse biological functions and due to their involvement in different diseases, including oral inflammatory diseases. Based on ncRNAs' suitability for salivary biomarkers and their involvement in neuropathic pain and tissue regeneration signaling pathways, the present narrative review aims to highlight the potential clinical applications of ncRNAs in oral inflammatory diseases, with an emphasis on salivary diagnostics, regenerative dentistry, and precision medicine for neuropathic orofacial pain.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368403PMC
http://dx.doi.org/10.3390/ijms23158278DOI Listing

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