AI Article Synopsis
- The lymph node ratio (LNR) measures the proportion of metastatic lymph nodes to the total number of lymph nodes and is known to have prognostic value in papillary thyroid carcinoma (PTC) and other solid tumors.
- This study analyzed 307 patients with PTC and lateral lymph node metastases to explore the link between LNR and disease-free survival (DFS), focusing on central-compartment LNR (CLNR) and lateral-compartment LNR (LLNR).
- Findings revealed that while LNR and LLNR didn't significantly influence recurrence rates, higher CLNR levels were associated with a greater risk of tumor recurrence, indicating that CLNR is an important predictor of prognosis in these patients.
Article Abstract
The lymph node ratio (LNR) indicates the number of metastatic lymph nodes (LNs) to the total number of LNs. The prognostic value of LNR in papillary thyroid carcinoma (PTC) and other solid tumors is known. This study aimed to investigate the relationship between LNR and disease-free survival (DFS) in patients with PTC with lateral LN metastases (N1b PTC). A total of 307 patients with N1b PTC who underwent total thyroidectomy and therapeutic central and lateral LN dissection were retrospectively analyzed. The DFS and recurrence risk in the patients with LNR, central-compartment LNR (CLNR), and lateral-compartment LNR (LLNR) were compared. The mean follow-up duration was 93.6 ± 19.9 months. Eleven (3.6%) patients experienced recurrence. Neither LNR nor LLNR affected the recurrence rate in our analysis ( 0.058, 0.106, respectively). However, there was a significant difference in the recurrence rates between the patients with low and high CLNR (2.1% vs. 8.8%, 0.017). In the multivariate analysis, CLNR ≥ 0.7 and perineural invasion were independent predictors of tumor recurrence. High CLNR was associated with an increased risk of recurrence, and was shown to be a significant predictor of prognosis in patients with N1b PTC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367408 | PMC |
| http://dx.doi.org/10.3390/cancers14153677 | DOI Listing |
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