Different pathotypes of can cause severe diseases in animals and humans. Wildlife may contribute to the circulation of pathogenic pathotypes, including enteropathogenic (EPEC), Shiga toxin-producing (STEC), and enterohemorrhagic (EHEC). This study analyzed 109 DNA samples previously extracted from fecal specimens collected from red foxes () to detect virulence genes , , , and , that characterize the EPEC, STEC, and EHEC strains. Thirty-one (28.4%) samples were positive for at least one investigated virulence gene: gene was detected in 21 (19.2%) samples, in 10 (9.1%), in 6 (5.5%), and in 4 (3.6%). Nine DNA samples resulted positive for two or three virulence genes: five (4.6%) samples were positive for and genes, two (1.8%) for and , one (0.9%) for and , one (0.9%) for , and . Red foxes seem to be involved in the epidemiology of these infections and their role could be relevant because they may be source of pathogenic for other wild animals, as well as domestic animals and humans.
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http://dx.doi.org/10.3390/ani12151959 | DOI Listing |
BMC Genomics
January 2025
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue 1095, Wuhan, Hubei, 430030, China.
Background: Left-right (LR) asymmetry disorders present a complex etiology, with genetic factors emerging as a primary contributor. This study aims to explore the genetic underpinnings of chromosomal variants and individual genes in fetuses afflicted with prenatal LR asymmetry disorder.
Methods: Through a retrospective analysis conducted between 2020 and 2023 at Tongji Hospital, Huazhong University of Science and Technology, genetic outcomes of LR asymmetric disorder were scrutinized utilizing copy number variation sequencing (CNV-seq) and whole exome sequencing (WES) methodologies.
Neurotherapeutics
January 2025
Department of Psychiatry, Washington University in St Louis, St Louis, MO, USA; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University in St Louis, St Louis, MO, USA. Electronic address:
Autosomal dominant Alzheimer's disease (ADAD) is driven by rare variants in APP, PSEN1, and PSEN2. Although more than 200 pathogenic variants in these genes are known to cause ADAD, other variants are benign, may act as risk factors, or may even reduce Alzheimer's disease risk (e.g.
View Article and Find Full Text PDFCell Signal
January 2025
Department of Biochemistry and Molecular Biology, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan 030001, China. Electronic address:
Hepatic stellate cells (HSCs) are the central link of the occurrence and development of hepatic fibrosis, and autophagy promotes HSCs activation. N6-methyladenosine (m6A) RNA modification can also control autophagy by targeting selected autophagy-associated genes. but up to now, little research has been done on the m6A modification autophagy-related genes (ATGs) in hepatic fibrosis.
View Article and Find Full Text PDFVet Microbiol
January 2025
Guangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, Innovative Institute of Animal Healthy Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China. Electronic address:
Acinetobacter johnsonii is a denitrifying bacterium commonly used as an environmental probiotic in wastewater treatment. However, research on its potential pathogenicity to animals is limited. During an epidemiological survey conducted from 2022 to 2024 at bullfrog farms in Guangdong Province, China, multiple strains were isolated from diseased bullfrogs during the low-temperature season.
View Article and Find Full Text PDFDiagn Microbiol Infect Dis
January 2025
Faculdade de Medicina, Instituto de Educação Médica (IDOMED), Universidade Estácio de Sá, Rio de Janeiro, Brazil; Centro de Informação em Saúde para Viajantes, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:
International travel facilitates the acquisition and carriage of extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E). We describe genomes of predominant ESBL-E clones detected before and after travel among subjects departing from Rio de Janeiro, Brazil, during 2015-2021, and genomes publicly available from countries visited by travelers. WGS (Illumina NovaSeq) was performed on 70 ESBL-E isolates from 66 travelers (18 pre- and 52 post-travel).
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