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Chromothripsis-Mediated Small Cell Lung Carcinoma.
Cancer Discov
January 2025
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Small cell lung carcinoma (SCLC) is a highly aggressive malignancy that is typically associated with tobacco exposure and inactivation of RB1 and TP53 genes. Here, we performed detailed clinicopathologic, genomic, and transcriptomic profiling of an atypical subset of SCLC that lacked RB1 and TP53 co-inactivation and arose in never/light smokers. We found that most cases were associated with chromothripsis-massive, localized chromosome shattering-recurrently involving chromosome 11 or 12 and resulting in extrachromosomal amplification of CCND1 or co-amplification of CCND2/CDK4/MDM2, respectively.
View Article and Find Full Text PDFMinimal Access vs Conventional Nipple-Sparing Mastectomy.
JAMA Surg
October 2024
Department of Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea.
Importance: While nipple-sparing mastectomy (NSM) for breast cancer was only performed using the open method in the past, its frequency using endoscopic and robotic surgical instruments has been increasing rapidly. However, there are limited studies regarding postoperative complications and the benefits and drawbacks of minimal access NSM (M-NSM) compared with conventional NSM (C-NSM).
Objective: To examine the differences in postoperative complications between C-NSM and M-NSM.
Integrated Clinical Genotype-Phenotype Characteristics of STAT3-Mutated Myeloid Neoplasms.
Clin Cancer Res
October 2024
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Article Synopsis
- STAT3 is a transcription factor involved in cancer progression, primarily through phosphorylation in myeloid neoplasms (MN), with mutations being rare.
- In a study of 32 cases, STAT3 mutations were found with a frequency of less than 0.5%, predominantly in acute myeloid leukemia, myelodysplastic syndrome, and chronic myelomonocytic leukemia.
- These mutations often co-occurred with other mutations and were linked to adverse disease characteristics, suggesting that identifying STAT3 mutations could be crucial for targeted therapies in MN patients.
Letter to the Editor There are benefits of subtyping hepatocellular adenoma also in men. Following-up on the publication by González IA et al. Clinicopathologic characterization of hepatocellular adenomas in men: A multicenter experience. Hum Pathol. 2023.
Hum Pathol
July 2024
Univ. Bordeaux, INSERM, BRIC, U1312, Bordeaux, France.
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