The ongoing Russia-Ukraine war is the most prominent conflict in Europe since the Second World War and has several geopolitical, economic, infrastructure, and health implications. The war has serious negative consequences on people and the planet. The damage to industrial and commercial infrastructure can contaminate water sources, which can be hazardous for human and ecosystem health. Water shortages and deteriorating sanitary conditions are already evident since water supply and sanitary infrastructure have been hit. Air quality is adversely affected due to troop movement and constant bombarding. Chances of radiation leakage from nuclear sites also remain. The physical, chemical and biological characteristics of soil have been impacted due to shelling and explosions, as a result of which, agriculture has been severely affected. Military actions have caused large-scale deforestation and even wildfires. There is also fear of biodiversity loss and species extinction in the long term. The war of such nature may directly hamper efforts to deal with aspects such as climate change, sustainable development goals (SDGs), conservation and protection of biodiversity, and pollution control at local and global levels. Besides this, the repercussions of this war on essential services such as healthcare, education, social security, and public amenities will be felt for a long. As a result of important interruptions in the supply of energy and raw materials throughout the world, prices for commodities, oil, and food have risen dramatically. To avert such damages in the future and make the offenders accountable, in the long term, reforms in the mandate of the International Criminal Court are required to include environmental crimes. New international norms to safeguard the environment during conflict are urgently needed. The environment should not be considered an unavoidable war casualty. Environmental and human security are inextricably linked. The international community's reaction to the crisis must include addressing this as a priority.
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http://dx.doi.org/10.1016/j.scitotenv.2022.157932 | DOI Listing |
BMC Pregnancy Childbirth
December 2024
Kumamoto University Regional Centre, The Japan Environment and Children's Study (JECS), 718, Medical Research Building, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan.
Background: Antinuclear antibodies (ANA) are important biomarkers for the diagnosis of autoimmune diseases; however, the general population also tests positive at a low frequency, especially in women. Although the effects of various autoimmune diseases on pregnancy outcomes have been studied, the association of ANA with pregnancy outcomes in healthy individuals is unclear. Preterm birth (PTB), a major cause of neonatal death or long-term health problems, is a complex condition with a multifactorial etiology, and the underlying mechanism remains unclear.
View Article and Find Full Text PDFBMC Med Educ
December 2024
Department of Orthopedics, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, 151203, India.
Generative Artificial Intelligence (AI), characterized by its ability to generate diverse forms of content including text, images, video and audio, has revolutionized many fields, including medical education. Generative AI leverages machine learning to create diverse content, enabling personalized learning, enhancing resource accessibility, and facilitating interactive case studies. This narrative review explores the integration of generative artificial intelligence (AI) into orthopedic education and training, highlighting its potential, current challenges, and future trajectory.
View Article and Find Full Text PDFCardiovasc Diabetol
December 2024
Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, s7-119, New York, NY, USA.
Background: Long-term consumption of Western Diet (WD) is a well-established risk factor for the development of cardiovascular disease (CVD); however, there is a paucity of studies on the long-term effects of WD on the pathophysiology of CVD and sex-specific responses.
Methods: Our study aimed to investigate the sex-specific pathophysiological changes in left ventricular (LV) function using transthoracic echocardiography (ECHO) and LV tissue transcriptomics in WD-fed C57BL/6 J mice for 125 days, starting at the age of 300 through 425 days.
Results: In female mice, consumption of the WD diet showed long-term effects on LV structure and possible development of HFpEF-like phenotype with compensatory cardiac structural changes later in life.
BMC Genomics
December 2024
College of Physics and Electronic Information, Gannan Normal University, Ganzhou, 341000, Jiangxi, China.
Long non-coding RNAs (lncRNAs) play crucial roles in numerous biological processes and are involved in complex human diseases through interactions with proteins. Accurate identification of lncRNA-protein interactions (LPI) can help elucidate the functional mechanisms of lncRNAs and provide scientific insights into the molecular mechanisms underlying related diseases. While many sequence-based methods have been developed to predict LPIs, efficiently extracting and effectively integrating potential feature information that reflects functional attributes from lncRNA and protein sequences remains a significant challenge.
View Article and Find Full Text PDFCardiovasc Revasc Med
December 2024
Department of Cardiology and Catheterization Laboratories, Shonan Kamakura General Hospital, Okamoto 1370-1, Kamakura City, Kanagawa 247-8533, Japan. Electronic address:
Background/purpose: Transcatheter aortic valve replacement (TAVR) with ACURATE neo2 showed better hemodynamic outcomes by mitigating paravalvular leakage (PVL) compared with ACURATE neo, and revealed promising one-year outcomes in single-arm studies. However, studies comparing the hemodynamic and clinical outcomes of the two valves are still scarce. Therefore, this study aimed to compare the one-year hemodynamic and clinical outcomes between the neo2 and neo.
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