A new type of photonic crystal gel molecularly imprinted sensor (MIPHs) was synthesized for the visible chiral recognition of amino acids. The color of MIPHs was changed from green to red when it exposured to various l-pyroglutamic acid concentration (0.05-1.0mmoL/L). Thanks to sensitive reflectance of photonic crystal and high selectivity of MIPs, the constructed MIPHs exhibited good performance towards l-pyroglutamic acid in terms of fast response time (3 min) and low detection limit (LOD) (2.4 μmol/L). Besides, MIPHs was found to have good selectivity toward l-pyroglutamic acid in the presence of interference group with similar structures such as d-pyroglutamic acid, l-tryptophan, l-phenylalanine, and l-proline. In light of these findings, the MIPHs can be used for highly selective recognition of l-pyroglutamic acid. It is expected that our work is able to provide a new roadmap for the chiral identification and separation of amino acids.
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