AI Article Synopsis
- Tough bioadhesion is important for engineering and medicine, but it's difficult to create and manage effectively.
- Researchers developed a method using ultrasound to boost the strength and durability of bioadhesive bonds, enhancing adhesion energy and fatigue resistance without any chemical reactions.
- The technique relies on ultrasound-induced cavitation to improve the bonding process, allowing for precise patterns, easy detachment, and effective drug delivery through the skin.
Article Abstract
Tough bioadhesion has important implications in engineering and medicine but remains challenging to form and control. We report an ultrasound (US)-mediated strategy to achieve tough bioadhesion with controllability and fatigue resistance. Without chemical reaction, the US can amplify the adhesion energy and interfacial fatigue threshold between hydrogels and porcine skin by up to 100 and 10 times. Combined experiments and theoretical modeling suggest that the key mechanism is US-induced cavitation, which propels and immobilizes anchoring primers into tissues with mitigated barrier effects. Our strategy achieves spatial patterning of tough bioadhesion, on-demand detachment, and transdermal drug delivery. This work expands the material repertoire for tough bioadhesion and enables bioadhesive technologies with high-level controllability.
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| http://dx.doi.org/10.1126/science.abn8699 | DOI Listing |
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