AI Article Synopsis
- Iron is crucial for brain function, but too much can cause cognitive and neurological issues, especially in neurodegenerative diseases.
- A study estimated the heritability of brain iron concentrations in 130 participants, finding a strong genetic influence (ranging from 0.46 to 0.82) on iron levels in different brain regions while noting that age and BMI had a minor impact.
- Distinct genetic factors control iron levels in the basal ganglia and cortex, indicating that these brain regions are influenced by different sets of genes.
Article Abstract
Background: While iron is essential for normal brain functioning, elevated concentrations are commonly found in neurodegenerative diseases and are associated with impaired cognition and neurological deficits. Currently, only little is known about genetic and environmental factors that influence brain iron concentrations.
Methods: Heritability and bivariate heritability of regional brain iron concentrations, assessed by R2* relaxometry at 3 Tesla MRI, were estimated with variance components models in 130 middle-aged to elderly participants of the Austrian Stroke Prevention Family Study.
Results: Heritability of R2* iron ranged from 0.46 to 0.82 in basal ganglia and from 0.65 to 0.76 in cortical lobes. Age and BMI explained up to 12% and 9% of the variance of R2* iron, while APOE ε4 carrier status, hypertension, diabetes, hypercholesterolemia, sex and smoking explained 5% or less. The genetic correlation of R2* iron among basal ganglionic nuclei and among cortical lobes ranged from 0.78 to 0.87 and from 0.65 to 0.97, respectively. R2* rates in basal ganglia and cortex were not genetically correlated.
Conclusions: Regional brain iron concentrations are mainly driven by genetic factors while environmental factors contribute to a certain extent. Brain iron levels in the basal ganglia and cortex are controlled by distinct sets of genes.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467397 | PMC |
| http://dx.doi.org/10.18632/aging.204212 | DOI Listing |
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