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Changes in hippocampal volume, 5-HT receptor binding, and verbal memory over the course of antidepressant treatment in major depressive disorder.
J Psychiatr Res
November 2024
Neurobiology Research Unit and BrainDrugs, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark; Mental Health Center Copenhagen, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Article Synopsis
- - Serotonin reuptake inhibitors may help boost memory and increase hippocampal volume in patients with Major Depressive Disorder (MDD), particularly through the involvement of the 5-HT4 receptor. - In a study with 91 patients, significant reductions in hippocampal volume were observed after 8 weeks of treatment, especially in those responding well to the antidepressant escitalopram. - The research indicated a negative relationship between 5-HT4 receptor binding and hippocampal volume in females, suggesting a complex interaction that needs further exploration to understand its impact on memory and brain plasticity in MDD.
Synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5-HT receptors with potential interest in the treatment of Alzheimer's disease.
Eur J Med Chem
December 2024
Université de Caen Normandie, Normandie Univ., Centre d'Etudes et de Recherche sur le Médicament de Normandie (CERMN), 14000 Caen, France. Electronic address:
In this work, we exemplified the "copride" family of drug candidates able to both inhibit acetylcholinesterase and to activate 5-HT receptors, with anti-amnesiant and promnesiant activities in mice. Twenty-one analogs of donecopride, the first-in class representative of the series, were synthesized exploring the influence on the biological activities of the substituents (methoxy, amine and chlorine) carried by its phenyl ring. This work was the support of an intensive structure-activity relationship study and allowed to obtain some interesting derivatives of donecopride.
View Article and Find Full Text PDFMechanism of action of FoxiangSan in diabetic gastroparesis: Gut microbiota and cAMP/PKA pathway.
Heliyon
August 2024
Department of Endocrinology, Beijing University of Chinese Medicine, Dongzhimen Hospital, Beijing, 100700, PR China.
Diabetic gastroparesis, a common complication of type 2 diabetes (T2DM), presents a significant treatment challenge. is emerging as a potential therapy. is a traditional Chinese medicine formula with the potential for treating diabetic gastroparesis by modulating gut microbiota and cAMP/PKA signaling pathways.
View Article and Find Full Text PDFEffect of Antidepressant Treatment on 5-HT Receptor Binding and Associations With Clinical Outcomes and Verbal Memory in Major Depressive Disorder.
Biol Psychiatry
February 2025
Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Psychiatric Center Copenhagen, Copenhagen, Denmark. Electronic address:
Background: Brain serotonin 4 receptor (5-HTR) levels are lower in untreated patients with major depressive disorder (MDD) and are linked to verbal memory. Here, we investigated the relationship between 5-HTR levels, clinical outcomes, and cognitive function in patients with MDD who initiated selective serotonin reuptake inhibitor drug treatment.
Methods: Ninety patients with moderate to severe depression underwent molecular brain imaging to measure 5-HTR binding prior to antidepressant treatment with escitalopram.
Effects of a 5-HT receptor antagonist in the caudate nucleus on the performance of macaques in a delayed reward task.
Sci Rep
August 2024
Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba, 263-8555, Japan.
Temporal discounting, in which the recipient of a reward perceives the value of that reward to decrease with delay in its receipt, is associated with impulsivity and psychiatric disorders such as depression. Here, we investigate the role of the serotonin 5-HT receptor (5-HTR) in modulating temporal discounting in the macaque dorsal caudate nucleus (dCDh), the neurons of which have been shown to represent temporally discounted value. We first mapped the 5-HTR distribution in macaque brains using positron emission tomography (PET) imaging and confirmed dense expression of 5-HTR in the dCDh.
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