AI Article Synopsis
- - The study of cyanobacterium sp. NIES-1697 led to the discovery of nostosin G, a linear tripeptide, spiroidesin B, and two known compounds, anabaenopeptins I and J.
- - The structures and configurations of nostosin G and spiroidesin B were analyzed using advanced techniques including 2D NMR, HRMS, and chiral-phase HPLC.
- - Nostosin G is notable for its unique structure made of three different components and exhibits potent inhibition of the enzyme trypsin; the researchers also explored the biosynthetic gene clusters related to both nostosin G and spiroidesin B based on genome sequencing.
Article Abstract
Chemical investigation of the cyanobacterium sp. NIES-1697 afforded nostosin G (), a linear tripeptide, spiroidesin B (), and two known compounds, anabaenopeptins I () and J (). Planar structures and absolute configurations for and were determined by 2D NMR, HRMS, Marfey's methodology, chiral-phase HPLC, and enzymatic degradation. Nostosin G () is a unique example of a linear peptide containing three subunits, 4-hydroxyphenyllactic acid (Hpla), homotyrosine (Hty), and argininal, with potent trypsin inhibitory properties. The biosynthetic gene clusters for nostosin G () and spiroidesin B () were investigated based on the genome sequence of sp. NIES-1697.
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| http://dx.doi.org/10.1021/acs.jnatprod.2c00382 | DOI Listing |
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