AI Article Synopsis
- Pore-forming proteins quickly cause cell lysis during infections, but processes like epithelial extrusion take longer to activate.
- Nozaki et al. (2022) discovered that caspase-7 plays a crucial role in membrane repair by activating acid sphingomyelinase (ASM), which helps manage the damage from pore formation.
- This mechanism allows for a delay in cell death, providing cells more time to respond to the infection.
Article Abstract
During infection, pore-forming proteins rapidly initiate cell lysis, but specialized processes like epithelial extrusion need additional time to occur in parallel. In a recent issue of Nature, Nozaki et al. (2022) report that caspase-7 promotes acid shingomyelinase (ASM)-mediated membrane repair of gasdermin and perforin pores to delay cell death.
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| http://dx.doi.org/10.1016/j.immuni.2022.07.013 | DOI Listing |
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