A type of quinoxaline-derived tridentate ,,-ligand was synthesized in good to excellent yields over three steps through iodination of 2-aryl indoles, sequential Kornblum-type oxidation with DMSO, and capture by 1,2-diaminobenzenes. The prepared atropisomeric ,,-ligand was successfully applied in the synthesis of -vinyl cinnamaldehyde nitrones as only -isomers in good yields through the Chan-Lam reaction. The method features an easily accessed tunable tridentate ,,-ligand, broad substrate scope, good functional group tolerance, and high -isomer for -vinyl nitrones.
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