AI Article Synopsis
- Researchers optimized a mechanochemical grinding method for synthesizing -substituted amines using common halides and amines.
- The process is suitable for large-scale production and occurs under mild conditions.
- Benefits include quick reaction times, room temperature operation, and high product yields without the need for column chromatography.
Article Abstract
Herein, we have optimized a highly efficient and neat mechanochemical grinding procedure for the facile synthesis of -substituted amines using easily available substituted halides and amines. The developed protocol is applicable for gram scale synthesis as well. Advantageous features of this strategy include mild and neat reaction conditions, a short reaction time at room temperature and isolation of products without column chromatography in excellent yields.
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| http://dx.doi.org/10.1039/d2ob01148d | DOI Listing |
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