AI Article Synopsis
- A new photochemical method has been developed for selectively alkylating the C7 position of benzocore compounds through the cross-coupling of coumarins with NHPI esters using Ru(II) as a photocatalyst under visible light.
- The reaction shows a wide variety of substrates can be used and is compatible with many functional groups, making it versatile.
- Investigations through controlled experiments and DFT calculations helped clarify the reaction mechanisms, particularly regarding how regioselectivity is achieved.
Article Abstract
An unprecedented, straightforward photochemical platform for efficient site-selective C-H alkylation of the C7 position of the benzocore the cross coupling between coumarins and NHPI esters, employing Ru(II) as a photocatalyst in visible light, has been reported. Remarkably, this transformation demonstrated broad substrate scope and good functional group compatibility. Controlled experiments and DFT calculations shed some insight into the mechanistic details of the reaction and allowed us to propose a plausible mechanism for the regioselectivity.
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| http://dx.doi.org/10.1039/d2cc03073j | DOI Listing |
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