AI Article Synopsis
- Pemigatinib is an FGFR inhibitor approved for treating biliary tract cancer with FGFR2 fusion.
- A case is reported of a 54-year-old woman with advanced cholangiocarcinoma who developed serious ocular side effects (SRD) after starting pemigatinib.
- Adjusting the dosage of pemigatinib resulted in the patient's SRD fully recovering while still continuing to see a reduction in tumor size.
Article Abstract
Pemigatinib is a fibroblast growth factor receptor inhibitor (FGFRi) approved for the treatment of patients with previously treated biliary tract cancer with FGFR2 fusion. Although infrequent, ocular toxicity manifested as serous retinal detachment (SRD) has been observed and is regarded as a serious side effect. We herein report the case of a 54-year-old woman with unresectable cholangiocarcinoma-initiated pemigatinib after failure of gemcitabine plus S-1 (GS). Although the patient experienced repeated SRD after pemigatinib, dose interruption and dose reduction of pemigatinib from 13.5 mg to 9 mg, and from 9 mg to 4.5 mg led to complete recovery of SRD, and continued tumor shrinkage.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183291 | PMC |
| http://dx.doi.org/10.2169/internalmedicine.0150-22 | DOI Listing |
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