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Novel immune drug combination induces tumour microenvironment remodelling and reduces the dosage of anti-PD-1 antibody.
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March 2025
Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.
Immune checkpoint inhibitors (ICIs) are effective in clinical settings; however, they present immune-related adverse effects and financial burden. Although dose reduction of ICIs may mitigate these limitations, it could compromise therapeutic efficacy. Using two adjuvants (poly(I:C) and LAG-3-Ig) combined with three neoantigen peptides (Comb), we examined whether Comb could enhance the efficacy of reduced dose of αPD-1 monoclonal antibody (RD-αPD-1 mAb), which has limited efficacy.
View Article and Find Full Text PDFOptically tunable catalytic cancer therapy using enzyme-like chiral plasmonic nanoparticles.
Nat Commun
March 2025
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, Republic of Korea.
Cascade enzymatic reactions in living organisms are fundamental reaction mechanisms in coordinating various complex biochemical processes such as metabolism, signal transduction, and gene regulation. Many studies have attempted to mimic cascade reactions using nanoparticles with enzyme-like activity; however, precisely tuning each reaction within complex networks to enhance the catalytic activity remains challenging. Here, we present enzyme-like chiral plasmonic nanoparticles for optically tunable catalytic cancer therapy.
View Article and Find Full Text PDFReducing the road freight emissions through integrated strategy in the port cities.
Nat Commun
March 2025
School of Architecture, Harbin Institute of Technology, Shenzhen, China.
Port cities, as crucial nodes in global supply chains, face challenges from both intense traffic emissions and vulnerability to climate-related extremes due to pollution density. Effective and near-term mitigation strategies for greener road freight are imperative to reverse the increasing trend of emissions. This study utilizes a high-resolution emission inventory from 1.
View Article and Find Full Text PDFCaspase 9-induced apoptosis enables efficient fetal cell ablation and disease modeling.
Nat Commun
March 2025
Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Fetal cell ablation models are crucial for studying congenital diseases, organ regeneration, and xenotransplantation. However, conventional knockout models offer limited control over disease severity, while conditional ablation models often require fetus-harming inducers. In the present study, we demonstrate that the inducible caspase 9 system enables precise targeting of fetal nephron progenitor cells in mice through the intrinsic apoptotic pathway.
View Article and Find Full Text PDFBranching architecture affects genetic diversity within an individual tree.
J Theor Biol
March 2025
Department of Biology, Faculty of Science, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
While a tree grows over many years, somatic mutations accumulate and form genetic variation among branches within an individual. Trees can transmit such mutations to subsequent generations, potentially enhancing the genetic diversity of the population. We study a mathematical model to understand the relationship between within-individual genetic variation and branching architecture.
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