Oridonin Inhibits SARS-CoV-2 Oridonin, a natural product extracted from , possesses a wide range of pharmacological properties, including anti-inflammatory, anti-cancer, anti-microbial, neuroprotection, immunoregulation, etc. In article number 2100124, Baisen Zhong, Litao Sun, and co-workers demonstrate that Oridonin targets the SARS-CoV-2 3CL protease by covalently binding to cysteine145 in its active pocket to exert an anti-SARS-CoV-2 effect, which provides a novel candidate for the treatment of COVID-19.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347789 | PMC |
| http://dx.doi.org/10.1002/smsc.202270012 | DOI Listing |
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