AI Article Synopsis
- Cancer cachexia is a serious condition that causes weight loss and muscle weakness in cancer patients, and there aren’t many good treatments for it.
- In a study with mice that have lung cancer, researchers found that a protein called Activin A makes cachexia worse, but using a special combination of two drugs helped improve muscle health and increased how much the mice ate.
- The treatment worked better in female mice and showed that women with certain types of lung cancer might need different therapies to help with cachexia than men do.
Article Abstract
Cancer cachexia is a common, debilitating condition with limited therapeutic options. Using an established mouse model of lung cancer, we find that cachexia is characterized by reduced food intake, spontaneous activity, and energy expenditure accompanied by muscle metabolic dysfunction and atrophy. We identify Activin A as a purported driver of cachexia and treat with ActRIIB-Fc, a decoy ligand for TGF-β/activin family members, together with anamorelin (Ana), a ghrelin receptor agonist, to reverse muscle dysfunction and anorexia, respectively. Ana effectively increases food intake but only the combination of drugs increases lean mass, restores spontaneous activity, and improves overall survival. These beneficial effects are limited to female mice and are dependent on ovarian function. In agreement, high expression of Activin A in human lung adenocarcinoma correlates with unfavorable prognosis only in female patients, despite similar expression levels in both sexes. This study suggests that multimodal, sex-specific, therapies are needed to reverse cachexia.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360437 | PMC |
| http://dx.doi.org/10.1038/s41467-022-32135-0 | DOI Listing |
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