Methemoglobinemia in a 28-year-old woman treated with dapsone.

CMAJ

Schulich School of Medicine and Dentistry (Jacob, Schorr, Moist), Western University, London, Ont.; Health Research Methodology (Schorr), Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ont.; Kidney Clinical Research Unit (Moist), Division of Nephrology, Department of Medicine Western University, London, Ont.

Published: August 2022

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365429PMC
http://dx.doi.org/10.1503/cmaj.212015DOI Listing

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Methemoglobinemia in a 28-year-old woman treated with dapsone.

CMAJ

August 2022

Schulich School of Medicine and Dentistry (Jacob, Schorr, Moist), Western University, London, Ont.; Health Research Methodology (Schorr), Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ont.; Kidney Clinical Research Unit (Moist), Division of Nephrology, Department of Medicine Western University, London, Ont.

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We report a case of fatal methaemoglobinaema resulting from sodium nitrite poisoning. A 28 year old woman arrested in the emergency department following collapse. During resuscitation a venous blood gas revealed a methaemoglobin percentage of 81%.

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Methemoglobinemia is a blood disorder in which there is an elevated level of methemoglobin. In contrast to normal hemoglobin, methemoglobin does not bind to oxygen, which leads to functional anemia. The signs of methemoglobinemia often overlap with other cardiovascular and pulmonary diseases, with cyanosis being the key sign of methemoglobinemia.

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