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Nonpharmacological Management of Cancer-Related Cachexia: A Systematic Review.
Semin Oncol Nurs
January 2025
Nursing Department, Cyprus University of Technology, Limassol, Cyprus.
Objectives: Cancer-related cachexia affects approximately 50% to 80% of cancer patients and contributes significantly to cancer-related mortality, accounting for 20% of deaths. This multifactorial syndrome is characterized by systemic inflammation, anorexia, and elevated energy expenditure, leading to severe weight loss and muscle wasting. Understanding the underlying mechanisms is critical for developing effective interventions.
View Article and Find Full Text PDFLactate shuttling links histone lactylation to adult hippocampal neurogenesis in mice.
Dev Cell
January 2025
State Key Laboratory for Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100093, China. Electronic address:
Lactate has emerged as a central metabolic fuel and an important signaling molecule. Its availability participates in various brain functions. Although lactate homeostasis is vital for adult hippocampal neurogenesis and cognition, it is still unknown how shuttles lactate across the plasma membrane of neural stem cells (NSCs) to control their activity and neurogenic potential.
View Article and Find Full Text PDFRecollection-related fMRI effects in entorhinal cortex predict longitudinal memory change in healthy older adults.
Neurobiol Aging
December 2024
Center for Vital Longevity and School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX 75235, USA.
The present study examines whether structural and functional variability in medial temporal lobe (MTL) neocortical regions correlate with individual differences in episodic memory and longitudinal memory change in cognitively healthy older adults. To address this question, older adults were administered a battery of neuropsychological tests on three occasions: the second occasion one month after the first test session, and a third session three years later. Structural and functional MRI data were acquired between the first two sessions and included an in-scanner associative recognition procedure enabling estimation of MTL encoding and recollection fMRI BOLD effects.
View Article and Find Full Text PDFGender-specific effects of dydrogesterone on zebrafish liver metabolism after long-term exposure.
Aquat Toxicol
January 2025
SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, China.
Synthetic progestin dydrogesterone is widely used in gynecology and animal husbandry, leading to high environmental detection rates and concentrations. Dydrogesterone influences sex differentiation, gonad development, and spawning in fish. However, its impact on the liver, a vital organ for hormone production and detoxification, remains largely unknown.
View Article and Find Full Text PDFUtility of ultrasound in thoracic anesthesia.
Best Pract Res Clin Anaesthesiol
March 2024
Department of Anaesthesiology, Intensive care and Emergency Medicine, OLV Clinic, Aalst, Belgium. Electronic address:
The use of ultrasound (US) in the perioperative clinical management should be goal-directed, rapid, and reproducible. Thoracic US enables detailed examinations of vital structures, such as the airway, lung, pleural space, diaphragm, and heart. This chapter focuses on the value of US as a bedside tool to assess anatomy, guide procedures, and monitor vital organ function in patients undergoing thoracic surgery.
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