AI Article Synopsis
- - Saxitoxin (STX) is a powerful neurotoxin produced by toxic dinoflagellates and accumulates in shellfish, requiring monitoring due to its health risks.
- - Monitoring STX in shellfish is challenging because it’s classified as a chemical warfare agent, complicating the import of calibration standards for testing.
- - The study suggests using non-toxic variants of STX (called -STXs) as safe substitutes for calibration standards, which can aid in effective monitoring without violating chemical weapons regulations.
Article Abstract
Saxitoxin (STX) is a potent neurotoxin that is biosynthesized by toxic dinoflagellates and accumulated in shellfish via the food chain. STX and its various analogues are now monitored in shellfish by the hygiene authorities in many countries with instrumental analytical methods, which require calibration with standards. Unfortunately, STX is registered as a chemical warfare agent in Schedule 1 of the Chemical Weapons Convention, and this has made it difficult to import calibration standards into some countries. We aimed to avoid violation of the Chemical Weapons Convention and facilitate analyses by preparing calibration standards based on unnatural nontoxic antipodal STXs (-STXs) with the same physicochemical properties as natural STXs. Our findings demonstrate that the nontoxic -STXs can be safely utilized as alternative reference materials of STXs in the routine monitoring program by the local authorities and consequently can lead to reduced usage of STX.
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| http://dx.doi.org/10.1021/acs.analchem.2c00836 | DOI Listing |
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