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http://dx.doi.org/10.1016/j.gastha.2022.07.010 | DOI Listing |
Front Cell Dev Biol
June 2024
Department of Clinical Laboratory, Changzhi People's Hospital, Changzhi, China.
COVID-19 patients often suffer from post-COVID-19 acute sequelae (PASC). Pulmonary fibrosis has the most significant long-term impact on the respiratory health of patients, known as post-COVID-19 pulmonary fibrosis (PC19-PF). PC19-PF can be caused by acute respiratory distress syndrome (ARDS) or COVID-19-induced pneumonia.
View Article and Find Full Text PDFJ Biomed Mater Res A
April 2024
The University of Texas at Austin, Department of Biomedical Engineering, Austin, Texas, USA.
With new daily discoveries about the long-term impacts of COVID-19, there is a clear need to develop in vitro models that can be used to better understand the pathogenicity and impact of COVID-19. Here, we demonstrate the utility of developing a model of endothelial dysfunction that utilizes human induced pluripotent stem cell-derived endothelial progenitors encapsulated in collagen hydrogels to study the effects of COVID-19 on the endothelium. These cells form capillary-like vasculature within 1 week after encapsulation and treating these cell-laden hydrogels with SARS-CoV-2 spike protein resulted in a significant decrease in the number of vessel-forming cells as well as vessel network connectivity quantified by our computational pipeline.
View Article and Find Full Text PDFWith new daily discoveries about the long-term impacts of COVID-19 there is a clear need to develop models that can be used to better understand the pathogenicity and impact of COVID-19. Here we demonstrate the utility of developing a model of endothelial dysfunction that utilizes induced pluripotent stem cell-derived endothelial progenitors encapsulated in collagen hydrogels to study the effects of COVID-19 on the endothelium. We found that treating these cell-laden hydrogels with SARS-CoV-2 spike protein resulted in a significant decrease in the number of vessel-forming cells as well as vessel network connectivity.
View Article and Find Full Text PDFGastro Hep Adv
August 2022
Department of Internal Medicine, GI Alliance, Mansfield, Texas.
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