AI Article Synopsis
- A new wet tissue adhesive hydrogel (w-TAgel) was developed, which can detach on demand to reduce patient discomfort during removal.
- The hydrogel is created through a specific polymerization process using various materials, giving it strong mechanical properties suitable for dynamic wound healing.
- Its unique design allows for strong adhesion to wet tissues while enabling easy detachment at temperatures below 25°C, making it an advanced option for effective wound closure and hemostasis.
Article Abstract
Tissue adhesive with on-demand detachment feature is critically important since it can minimize hurt to patient when it is stripped away. Herein, a water-driven noninvasively detachable wet tissue adhesive hydrogel (w-TAgel) was produced by UV-initiated radical copolymerization of N-isopropylacrylamide (NIPAM), acrylamide (AAm), gelatin methacrylate (GelMA), and urushiol. As a w-TAgel, its robust and tough mechanical property makes it suitable for dynamic wound tissue. The polyurushiol segments of it are crucial to the formation of tough adhesion interface with various wet tissues, while polyNIPAM units play an indispensable role in on-demand detachment via thermo-responsive swelling behavior because the hydrophobic aggregation among isopropyl groups is destroyed upon water treatment with temperature of 25 °C or less. Additionally, it exhibits multiple merits including good hemocompatibility, cytocompatibility as well as pro-coagulant activity and hemostasis. Therefore, our w-TAgel with strong adhesion and facile detachment is an advanced prospective dressing for wound closure and rapid hemostasis. The wet tissue adhesion and water-driven detachable mechanism may shed new light on the development of on-demand noninvasively detachable wet tissue adhesives.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352973 | PMC |
| http://dx.doi.org/10.1016/j.mtbio.2022.100369 | DOI Listing |
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