Substituted thiazoles are widely known as natural products, approved drugs, and a number of synthetic compounds as bioactive agents. Due to the worth of this heterocycle nucleus, a large number of synthetic methodologies have been reported over the years to synthesize its derivatives. In this perspective, recent advances in the synthesis of thiazole compounds by using domino/cascade and multicomponent approaches have been summarized.
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| http://dx.doi.org/10.2174/1385272826666220214110118 | DOI Listing |
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Domino/Cascade and Multicomponent Reactions for the Synthesis of Thiazole Derivatives.
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The Department of Chemistry and Physics, College of Sciences and Mathematics, Arkansas State University, Jonesboro, AR 72401, USA.
Substituted thiazoles are widely known as natural products, approved drugs, and a number of synthetic compounds as bioactive agents. Due to the worth of this heterocycle nucleus, a large number of synthetic methodologies have been reported over the years to synthesize its derivatives. In this perspective, recent advances in the synthesis of thiazole compounds by using domino/cascade and multicomponent approaches have been summarized.
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Department of Pharmacy , University of Naples Federico II, via D. Montesano 49 , 80131 , Napoli , Italy.
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